Contemporary Biochemical Data on the Origin of Life in the Light of Theological Evaluation
DOI:
https://doi.org/10.31802/GB.2026.60.1.002Keywords:
biochemistry, origin of life, genetic code, theology, Logos, Divine Providence, patristics, evolution, complexity, philosophy of scienceAbstract
The article analyzes contemporary biochemical data on the origin of life and considers their interpretation in the context of theological evaluation. The aim of the study is to identify how the results of molecular biology, genetics, and chemistry concerning the genetic code and its stability correlate with the Christian understanding of the world as created and ordered by God. The methodology includes a review of recent scientific publications, a comparative analysis of biochemical models of the origin of life, and their critical evaluation in the light of patristic heritage and theological categories. The results show that hypotheses about the random emergence of genetic structures face serious limitations, whereas data on the optimality and robustness of the code allow it to be considered as an expression of a divine design. The significance of the study lies in developing a theologically integrated approach to the problem of the origin of life that takes into account both scientific data and spiritual‑moral foundations.
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Basilius Caesariensis. Homiliae in Hexaemeron (Τοῦ ἐν ἁγίοις πατρὸς ἡμῶν Βασιλείου ἀρχιεπισκόπου Καισαρείας Καππαδοκίας ὁμιλίαι θʹ εἰς τὴν Ἑξαήμερον) // PG. T. 29. Col. 3–208.
Joannes Damascenus. De Fide Orthodoxa (Ἔκδοσις ἀκριβὴς τῆς ὀρθοδόξου πίστεως) // PG. T. 94. Col. 789–1228.
Maximus Confessor. Ambiguorum Liber (Μαξίμου Περὶ διαφόρων ἀποριῶν) // PG. T. 91. Col. 1031–1418.
Василий Великий, свт. Творения: [в 2 т.] Т. 1: Догматико полемические творения. Экзегетические сочинения. Беседы. Прил.: архиеп. Василий (Кривошеин). Проблема познаваемости Бога. Москва: Сибирская Благозвонница, 2008. (ПСТСО; т. 3).
Иоанн Дамаскин, прп. Творения. Источник знания / пер. и комм. Д. Е. Афиногенова, А. А. Бронзова, А. И. Сагарды, Н. И. Сагарды. Москва: Индрик, 2002. (Святоотеческое наследие).
Лука (Войно Ясенецкий), свт. Избранные творения. Москва: Сибирская Благозвонница, 2010.
Максим Исповедник, прп. О различных недоумениях у святых Григория и Дионисия (Амбигвы) / пер. с греч., примеч. архим. Нектария. Москва: Институт философии, теологии и истории св. Фомы, 2006.
Attwater J., Augustin T. L., Curran J. F., et al. Trinucleotide Substrates under pH–Freeze–Thaw Cycles Enable Open Ended Exponential RNA Replication by a Polymerase Ribozyme // Nature Chemistry. 2025. Vol. 17. P. 1129–1137. DOI: 10.1038/s41557-025-01830-y
Copley S. D. Evolution of New Enzymes by Gene Duplication and Divergence // FEBS Journal. 2020. Vol. 287. № 7. P. 1262–1283. DOI: 10.1111/febs.15299
Copley S. D. Setting the Stage for Evolution of a New Enzyme // Current Opinion in Structural Biology. 2021. Vol. 69. P. 41–49. DOI: 10.1016/j.sbi.2021.03.001
Hlouchova K., Konvalinka J., Martins B. M. C., Damborsky J. Peptides en Route from Prebiotic to Biotic Catalysis // Accounts of Chemical Research. 2024. Vol. 57. № 15. P. 2027–2037. DOI: 10.1021/acs.accounts.4c00137
Kakizaki J., Mizuuchi R. Selection–Diversification Interplay in Oligonucleotide Chemical Evolution // Biophysics and Physicobiology. 2025. Vol. 22. № 4. DOI: 10.2142/biophysicobppb-v22.0028
Kato G. J., Piel F. B., Reid C. D., et al. Sickle Cell Disease // Nature Reviews Disease Primers. 2018. Vol. 4. Art. 18010. DOI: 10.1038/nrdp.2018.10
Lei L., Burton Z. F. Evolution of the Genetic Code // Transcription. 2021. Vol. 12. № 1. P. 28–53. DOI: 10.1080/21541264.2021.1927652
Listov D., Vos E., Hoffka G., et al. Complete Computational Design of High Efficiency Kemp Elimination Enzymes // Nature. 2025. Vol. 643. P. 1421–1427. DOI: 10.1038/s41586-025-09136-2
Miller B. J. A Methodology for Calculating the Rarity of Diverse Proteins Based on Functional Specificity and Thermodynamic Stability // PLoS One. 2025. Vol. 20. № 12. Art. e0339572. DOI: 10.1371/journal.pone.0339572
Omachi Y., Saito N., Furusawa C. Rare Event Sampling Analysis Uncovers the Fitness Landscape of the Genetic Code // PLoS Computational Biology. 2023. Vol. 19. № 4. Art. e1011034. DOI: 10.1371/journal.pcbi.1011034
Reis D. Q. P., Pereira S., Ramos A. P., et al. Catalytic Peptide Based Coacervates for Enhanced Function Through Structural Organization and Substrate Specificity // Nature Communications. 2024. Vol. 15. Art. 9368. DOI: 10.1038/s41467-024-53699-z
Salibi E., Peter B., Schwille P., et al. Periodic Temperature Changes Drive the Proliferation of Self Replicating RNAs in Vesicle Populations // Nature Communications. 2023. Vol. 14. Art. 1222. DOI: 10.1038/s41467-023-36940-z
Schnettler J. D., Wang M. S., Gantz M., et al. Selection of a Promiscuous Minimalist cAMP Phosphodiesterase from a Library of de novo Designed Proteins // Nature Chemistry. 2024. Vol. 16. P. 1200–1208. DOI: 10.1038/s41557-024-01490-4
Schopf J. W., Kitajima K., Spicuzza M. J., et al. SIMS Analyses of the Oldest Known Assemblage of Microfossils Document Their Taxon Correlated Carbon Isotope Compositions // Proceedings of the National Academy of Sciences of the United States of America. 2017. Vol. 115. № 1. P. 53–58. DOI: 10.1073/pnas.1718063115
Tong C. L., Lee K.-H., Seelig B. De Novo Proteins from Random Sequences Through in Vitro Evolution // Current Opinion in Structural Biology. 2021. Vol. 68. P. 129–134. DOI: 10.1016/j.sbi.2020.12.014
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